Zeek.
Alot depends on joining process and service conditions..
2XXX series alloys are commonly joined by resistance spot welding, but only a few 2XXX alloys are considered weldable by arc processes. 2014, 2219, and 2519 are the three arc-weldable alloys mentioned by the Aluminum Association in its "Welding Aluminum Theory and Practice". No 2XXX alloys are considered suitable for brazing.
Say more about the specific 2XXX series alloy you have selected, and maybe about process and service conditions too.
We are using an automatic TIG process to weld 2219-T87 to 6061-T6. Our filler wire of choice is 4043. I don't know the exact service conditions yet, but i'll post them up this afternoon.
The service conditions are pretty mild... The temperature of the part ranges from 40F to 90F max and the structure operates at 14.7psi, but is proof tested to 23.
I do not think you will have any problems with your choices.
We haven't been having any problems in regards to tensile testing because we are meeting our strength requirements. But, I don't know much in terms of the metallurgy or resulting material matrix that we are creating by welding these 2 alloys together in this manner. My concern is things like fatigue, corrosion properties, etc.