The Chicken gun...
So, What to do on a beautiful Wyoming Spring day at home and bored.
The internet rumor has it that some poor sap held a Smith and Wesson XVR 460 Magnum pistol improperly and blew his thumb off. Well, me and Michelle (OK, I coerced the poor darling into the roll of videographer) decided to play "MythBuster" and give it a go. Fortunately we used 2 camera set-ups. One failed to record in Slo-Mo, but the set-up shots with a still unit and the other video panned out.
Here's how the experiment was setup. Rubber banded some chicken wing parts onto a Smith and Wesson XVR 460 Magnum pistol at the cylinder gap to forcing cone and over the compensator on the muzzle.
See for yourself how the "hold my beer and watch this" turned out.
Lessons learned...
1) Color code the individual parts. 4 parts were affixed to the gun and only 2 partials were recovered.
2) Wear more PPE... primarily a face shield. 4 hours later we are both still picking skin, meat and bone from our hair, clothes and skin! My forehead and hands feel like I've been sand blasted.
3) Pretest all equipment prior to rolling the cameras.
4) DO! Hold a large caliber handgun properly. It WILL BLOW BODY PARTS CLEAN APART.

FOR THOSE UNFAMILIAR WITH THIS WEAPON PLATFORM...
The 460 is basically equivalent to a 45-70 rifle in a handgun.
Comparing this to a .44 magnum is like comparing a .22lr to a .38 special.

All comedy aside, PLEASE respect firearms.
Treat them as loaded at all times.
Don't try this at home. Your neighbors will not be amused.